Hydrophilic copolymer and medical device
AssigneeTerumo Kabushiki Kaisha
InventorsMasanori Kuramoto, Takao Anzai
Life of this patent
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Abstract
A hydrophilic copolymer that can form a surface lubricious layer exhibiting superior lubricating property and durability (lubrication retaining property), is provided. A hydrophilic copolymer having a good solvent solubility is provided. A hydrophilic copolymer is provided containing: structural units derived from a polymerizable monomer (A) having a sulfobetaine structure; structural units derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and groups of salts thereof; and structural units derived from a polymerizable monomer (C) having a photoreactive group.
Claims12
A medical device comprising:
- a substrate layer;
- and
- a surface lubricious layer that is formed on at least a part of a surface of the substrate layer, wherein the surface lubricious layer contains a hydrophilic copolymer comprising:
- structural units derived from a polymerizable monomer (A) having a sulfobetaine structure;
- structural units derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and groups of salts thereof;
- and
- structural units derived from a polymerizable monomer (C) having a photoreactive group,
- wherein the polymerizable monomer (B) is represented by the following formula (2):
- wherein
- R21 is a hydrogen atom or a methyl group,
- Z2 is an oxygen atom or —NH—,
- R22 is a straight chain or branched chain alkylene group having 1 to 20 carbon atoms, and
- X is a group selected from the group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and groups of salts thereof.
A medical device comprising:
- a substrate layer;
- and
- a surface lubricious layer that is formed on at least a part of a surface of the substrate layer, wherein the surface lubricious layer contains a hydrophilic copolymer comprising:
- structural units derived from a polymerizable monomer (A) having a sulfobetaine structure;
- structural units derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and groups of salts thereof;
- and
- structural units derived from a polymerizable monomer (C) having a photoreactive group,
- wherein the surface lubricious layer is bound to the substrate layer via the photoreactive group of the hydrophilic copolymer.
Dependencies are inferred from the claim text.