Methods and formulations for reducing reconstitution time of lyophilized polypeptides

A method for reducing reconstitution time of a lyophilized antibody composition, the method comprising:

• (a) preparing a liquid composition comprising the antibody and a sugar at a molar ratio of sugar:antibody of at least about 360:1, (b) adding tert-butyl alcohol (TBA) to the liquid composition to form a liquid antibody/TBA mixture, wherein the amount of TBA in the liquid antibody/TBA mixture is about 5%-6% by volume, (c) freezing the liquid antibody/TBA mixture, (d) lyophilizing the frozen antibody/TBA mixture to form a lyophilized antibody composition, (e) reconstituting the lyophilized antibody composition with a diluent, wherein the time for reconstituting the antibody lyophilized in the presence of TBA is less than the time for reconstituting the same amount of the same antibody lyophilized in the absence of TBA.