Antibody beneficial for treatment of solid tumors, antibody-drug conjugate, and cancer drug including same
AssigneesNational Cancer Center Japan, Rin Institute Inc.
InventorsYasuhiro Matsumura, Masahiro Yasunaga, Shinji Saijo, Ryo Tsumura
Life of this patent
Estimating the term…
Abstract
The present invention provides an antibody beneficial for treatment of a solid tumor, an antibody-drug conjugate thereof, and an anticancer agent comprising these. The present invention provides, for example, an antibody that binds to tissue factor or an antigen-binding fragment thereof, wherein the antibody has a dissociation rate constant kd of 5×10−4 s−1 or more and an association rate constant Ka of 1×104 M−1 s−1 or more.
Claims4
An antibody that binds to tissue factor, or an antigen-binding fragment thereof, wherein the antibody has a dissociation rate constant Kd of 5×10−4 s−1 or more and an association rate constant Ka of 1×104 M−1 s−1 or more, which comprises:
- a heavy chain variable region comprising complementarity-determining regions (CDRs) 1 to 3 having amino acid sequences of SEQ ID NOs:
- 2 to 4, respectively;
- and
- a light chain variable region comprising CDR 1 to 3 having amino acid sequences of SEQ ID NOs:
- 6 to 8, respectively.
Dependencies are inferred from the claim text.