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AssigneeRegeneron Pharmaceuticals, Inc.
InventorsJesper Gromada, Viktoria Gusarova, Amy Han, Sokol Haxhinasto, Christos Kyratsous, Andrew J. Murphy, Thomas Nittoli, William Olson, Matthew Sleeman, Anna Zumsteg
Estimating the term…
Provided herein are antibodies and antigen-binding fragments that bind MSR1 and methods of use thereof. According to certain embodiments, the antibodies bind human MSR1 with high affinity. In certain embodiments, the antibodies bind MSR1 without blocking, or blocking less than 90%, of modified LDL binding to MSR1. In some embodiments, the antibodies bind cell surface expressed-MSR1 and are internalized. The antibodies of the invention may be fully human antibodies. The invention includes anti-MSR1 antibodies, or antigen-binding fragments thereof, conjugated to drugs or therapeutic compounds.
An isolated antibody or antigen-binding fragment thereof that binds macrophage scavenger receptor 1 (MSR1), wherein the antibody or antigen-binding fragment comprises:
Dependencies are inferred from the claim text.