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US 11,377,499 B2Granted
Targeting the cofilin pathway
AssigneeGeorge Mason University
InventorYuntao Wu
Life of this patent
Estimating the term…
Abstract
The present disclosure provides a method of restoring immune reconstitution, immune control of viremia, and one or more T cell functions in a subject infected with HIV. The method includes administering to the subject infected with HIV an agent that targets the cofilin pathway.
Claims19
A method comprising:
- identifying cofilin hyperactivation by obtaining or having obtained a biological sample from a patient and performing or having performed an assay on the biological sample to profile cofilin phosphorylation;
- identifying loss of chemotaxis of T-cells in the biological sample;
- obtaining an agent comprising an anti-α4β7 integrin antibody and a chemokine comprising stromal cell-derived factor 1 (SDF-1), and administering the agent in the patient.
A method comprising:
- identifying cofilin hyperactivation by obtaining or having obtained a biological sample from a patient and performing or having performed an assay on the biological sample to profile cofilin phosphorylation;
- identifying loss of chemotaxis of T-cells in the biological sample;
- obtaining an agent comprising an anti-α4β7 integrin antibody and a chemokine comprising a molecule having an ability to bind at a chemokine receptor comprising CCR5 and/or CXCR4 and a chemotactic property, and administering the agent in the patient.
A method comprising:
- identifying cofilin hyperactivation by obtaining or having obtained a biological sample from a patient and performing or having performed an assay on the biological sample to profile cofilin phosphorylation;
- identifying loss of chemotaxis of T-cells in the biological sample;
- obtaining an agent comprising an anti-α4β7 integrin antibody and a chemokine comprising a molecule having a chemotactic property of stromal cell-derived factor 1 (SDF-1), and administering the agent in the patient.
Dependencies are inferred from the claim text.