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US 11,377,494 B2Granted
Antagonist antibodies against human immune checkpoint CEACAM1 (CD66a) and formulations, kits, and methods of use thereof
AssigneeAlbert Einstein College of Medicine
InventorXingxing Zang
Life of this patent
Estimating the term…
Abstract
Provided are isolated antibodies and antigen-binding fragments thereof that specifically bind CEACAM1, including the IgV domain of CEACAM1, as well as pharmaceutical formulations, kits, and methods of use thereof.
Claims12
An antibody or antigen-binding fragment thereof that specifically binds human CEACAM1, said antibody or antigen-binding fragment thereof comprising:
- (a) a heavy chain variable region comprising:
- (SEQ ID NO:
- 13)
- GYIFRNYGMN
- (SEQ ID NO:
- 14)
- WINTYTGEPTYADDFKG,
- and
- (SEQ ID NO:
- 15)
- RGWLLTGGAMDY;
- and
- a light chain variable region comprising:
- (SEQ ID NO:
- 16)
- RASQDIGSSLN,
- (SEQ ID NO:
- 17)
- ATSSLDS,
- and
- (SEQ ID NO:
- 18)
- LQYVSSPWT;
- (b) a heavy chain variable region comprising:
- (SEQ ID NO:
- 19)
- GYIFRNYGMN,
- (SEQ ID NO:
- 20)
- WINTYTGEPTYADDFKG,
- and
- (SEQ ID NO:
- 21)
- DCGTSHYYAMDY;
- and
- a light chain variable region comprising:
- (SEQ ID NO:
- 22)
- RASQDISNYLN,
- and
- (SEQ ID NO:
- 23)
- YTSRLHS,
- and
- (SEQ ID NO:
- 24)
- QQGNTFPLT;
- or
- (c) a heavy chain variable region comprising:
- (SEQ ID NO:
- 25)
- GYAFTIYLIE,
- (SEQ ID NO:
- 26)
- VINPGSGGTNYNEKFKG,
- and
- (SEQ ID NO:
- 27)
- SYYYGSFAMDY;
- a light chain variable region comprising:
- (SEQ ID NO:
- 28)
- RASQDIGNYLN,
- (SEQ ID NO:
- 29)
- YTSRLHS,
- and
- (SEQ ID NO:
- 30)
- QQGNTLRT.
67 more elements
Dependencies are inferred from the claim text.