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US 11,377,490 B2Granted
Method for treating cancer using disulfide-linked trimeric 4-1BBL
AssigneeSichuan Clover Biopharmaceuticals, Inc.
InventorPeng Liang
Life of this patent
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Abstract
Compositions of TNF family of cytokines in covalently linked trimeric forms are disclosed. The resulting fusion proteins are secreted as disulfide bond-linked homotrimers, which are more stable in structure and therapeutically more efficacious than their native counterparts.
Claims17
A method for treating cancer in a mammal, comprising a step of administering to said mammal a therapeutically effective amount of a disulfide bond-linked trimeric 4-1BBL fusion protein, wherein the disulfide bond-linked trimeric 4-1BBL the fusion protein comprises the amino acid sequence set forth in SEQ ID NO:
- 3 or SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.