US 11,377,489 B2 · Dual-targeting antibody targeting SCF and galectin-1 and use thereof

Abstract

The present invention relates to a dual-targeting antibody targeting stem cell factor (SCF) and galectin-1 and a composition for preventing or treating angiogenesis-related diseases comprising the same. The present invention provides a dual-targeting antibody derived from a human monoclonal antibody which may effectively inhibit angiogenesis by simultaneously neutralizing SCF and galectin-1 involved in angiogenesis, and a pharmaceutical composition for preventing or treating angiogenesis-related diseases comprising the antibody. The dual-targeting antibody according to the present invention may effectively prevent or treat angiogenesis-related diseases by simultaneously neutralizing two targets involved in angiogenesis wherein the angiogenesis-related diseases cause hemorrhaging by blood vessels changing due to abnormal angiogenesis and thus increasing the permeability thereof.

Claims11

Dependent claims

A dual-targeting antibody specifically binding to SCF (Stem Cell Factor) and galectin-1, wherein the dual-targeting antibody comprises:

a light-chain variable region comprising a light-chain CDR1 comprising the amino acid sequence of SEQ ID NO:
1, a light-chain CDR2 comprising the amino acid sequence of SEQ ID NO:
2, and a light-chain CDR3 comprising the amino acid sequence of SEQ ID NO:
3;
and
a heavy-chain variable region comprising a heavy-chain CDR1 comprising the amino acid sequence of SEQ ID NO:
4, a heavy-chain CDR2 comprising the amino acid sequence of SEQ ID NO:
5, and a heavy-chain CDR3 comprising the amino acid sequence of SEQ ID NO:
6.

6 more elements

Dependencies are inferred from the claim text.

Dual-targeting antibody targeting SCF and galectin-1 and use thereof

Life of this patent

Dual-targeting antibody targeting SCF and galectin-1 and use thereof

Life of this patent

Abstract

Claims11