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US 11,377,487 B2Granted
Factor H potentiating antibodies and uses thereof
AssigneeStichting Sanquin Bloedvoorziening
InventorsTaco Willem Kuijpers, Diana Wouters, Maria Clara Brouwer, Richard Benjamin Pouw
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Abstract
The invention relates to novel isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H. The invention further relates to the use of such antibodies and fragments for inhibiting complement activation and treatment of disorders associated with complement activation.
Claims26
An isolated, synthetic or recombinant antibody or antigen binding fragment thereof that specifically binds to complement control protein domain 18 (CCP18) of factor H (FH) comprising:
- a light chain CDR1 sequence having the sequence SSVXY, wherein X is R, T or N (SEQ ID NO:91) or the sequence QSLVHSNGNTY (SEQ ID NO:49),
- a light chain CDR2 sequence having the sequence X1X2S wherein X1=A, K or Y and X2=T or L (SEQ ID NO:92),
- a light chain CDR3 having a sequence selected from the group consisting of QQWGTKPPT (SEQ ID NO:19), QQRSSSNPLT (SEQ ID NO:35), SQSTHVPFT (SEQ ID NO:51) and QQFTSSPLT (SEQ ID NO:67),
- a heavy chain CDR1 having the sequence X1FSLTX2X3G, wherein X1=D or G, X2=N or S and X3=S or Y (SEQ ID NO:93),
- a heavy chain CDR2 having the sequence IWSGGXT, wherein x=T, N or S (SEQ ID NO:94), and
- a heavy chain CDR3 sequence having the sequence ARNX1GNYX2X3DY, wherein X1=F or G, X2=A or Y and X3=V, M or F (SEQ ID NO:95) or AKNGDYGYTMDY (SEQ ID NO:55).
3 more elements
Dependencies are inferred from the claim text.