Compounds to inhibit bacterial s-layer protein assembly
AssigneesVib Vzw, Vrij Universiteit Brussel
InventorsHan Remaut, Antonella Fioravanti
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Abstract
The present invention relates to the field of bacterial Surface (S)-layer proteins, in particular to compounds capable of disrupting the bacterial S-Layer, specifically the S-Layer of Bacillus anthracis. More particularly, the invention provides for single domain antibodies for diagnosis and treatment of infection caused by pathogens with an S-Layer, in particular of Bacillus anthracis infection. The invention relates to S-Layer protein binding agents inhibiting bacterial growth and interrupting S-Layer assembly, useful in the treatment of bacterial infection, more specifically treatment of anthrax disease.
Claims11
A molecule that specifically binds to a bacterial Surface-layer protein (SLP), wherein the binding of the molecule disintegrates the bacterial surface layer (S-Layer), wherein the molecule is a small molecule, a peptide, a peptidomimetic, an antibody mimetic, an immunoglobulin single variable domain, or an active antibody fragment.
Dependencies are inferred from the claim text.