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US 11,377,478 B2Granted
T-cell modulatory multimeric polypeptides and methods of use thereof
AssigneeCue Biopharma, Inc.
InventorsRonald D. Seidel, III, Rodolfo J. Chaparro
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AssigneeCue Biopharma, Inc.
InventorsRonald D. Seidel, III, Rodolfo J. Chaparro
Estimating the term…
The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.
A variant IL-2 polypeptide comprising an amino acid sequence having the amino acid sequence set forth in SEQ ID NO:44, wherein amino acid 16 is Ala and amino acid 42 is Ala.
A fusion polypeptide comprising:
A fusion polypeptide comprising:
Dependencies are inferred from the claim text.