US 11,377,474 B2Granted

Method for preparing AMG 416 (etelcalcetide)

AssigneeAmgen Inc.

InventorsJeroen Bezemer, Ying Chen, Richard Crockett, Kevin Crossley, Sheng Cui, Liang Huang, Sian Jones, Asher Lower, Krishnakumar Ranganathan

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A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.

Dependent claims

A method for preparing etelcalcetide, as set forth in formula (1):

or a pharmaceutically acceptable salt thereof, the method comprising:
contacting a peptide having the structure of Ac-D-Cys(SPy)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2 (SEQ ID NO:4) with L-Cys to produce a conjugated product of formula (1).

Dependencies are inferred from the claim text.

C07K 7/06
Linear peptides containing only normal peptide links: having 5 to 11 amino acids
C07K 1/1075
By covalent attachment of residues or functional groups: by covalent attachment of amino acids or peptide residues
A61K 38/00
Medicinal preparations containing peptides
A61P 5/20
Of the parathyroid hormones: for decreasing, blocking or antagonising the activity of PTH

From the US filing history. Foreign family members aren’t listed.

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