Functionalized heterocycles as antiviral agents
AssigneeEnanta Pharmaceuticals, Inc.
InventorsJoseph Panarese, Samuel Bartlett, Dexter Davis, Katherine Chong, Yat Sun Or
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Abstract
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Claims21
A compound represented by Formula (XIII-1) or Formula (XIII-2), or a pharmaceutically acceptable salt thereof:
- wherein R2 and R3 are selected from the group consisting of halogen, —CN, —CH3, —CF3, —CHF2, —C(O)CH3, —OCH3, —OCF3, —OCHF2, —OH, —OR11, —NH2, NHR12;
- or R2 and R3 are selected from the groups below by removal of a hydrogen atom
- wherein each of these groups is optionally substituted with one to four groups selected from halo, CN, optionally substituted C1-C6 alkyl, and optionally substituted 3- to 8-membered heterocyclic;
- or R2 and R3 are each selected from one of the following:
- wherein each R21 is independently selected from —CH3, —CHF2, —CF3, -isopropyl, -t-butyl, or one of the following by removal of a hydrogen atom:
- wherein each of these groups is optionally substituted with one to four groups selected from halo, CN, optionally substituted C1-C6 alkyl, and optionally substituted 3- to 8-membered heterocyclic;
- R11 and R12 are each independently selected from the following groups by removal of a hydrogen atom:
- and Q4 is optionally substituted —C1-C6 alkyl.
A compound having the structure
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.