Inhibitors of RAF kinases

A compound, or pharmaceutically acceptable salt or solvate thereof, having the structure of Formula (I):

• wherein,
• X is N or C—H;
• R1 is selected from H, optionally substituted C1-C6 alkyl, or optionally substituted C3-C7 cycloalkyl;
• R2 is selected from H, optionally substituted C1-C6 alkyl, or optionally substituted C3-C7 cycloalkyl;
• or optionally, R1 and R2 join to form a ring;
• R3 is selected from H, —OH, —OR4, —NH2, —NHR4, —N(R4)2, optionally substituted heterocyclyl, or optionally substituted heteroaryl;
• each R4 is independently selected from optionally substituted C1-C6 alkyl, optionally substituted C1-C6 acyl or optionally, R2 and R4 join to form a ring;
• and
• Z is an optionally substituted aryl or heteroaryl.