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US 11,377,429 B2Granted
Benzothia(di)azepine compounds and their use as bile acid modulators
AssigneeAlbireo AB
InventorsPer-Göran Gillberg, Ingemar Starke, Santosh S. Kulkarni
Life of this patent
Estimating the term…
Abstract
The invention relates to certain 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives as defined herein. These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.
Claims5
A compound of formula (I),
- wherein M, R1, R2, R3, R4, R5A and R5B are as indicated in Table 1 below:
- TABLE 1
- M
- R1
- R2
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH3
- CH2CH3
- CH2
- CH2CH3
- CH2CH3
- CH2
- CH2CH3
- CH2CH3
- CH2
- CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- CH2
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- NH
- CH2CH2CH3
- CH2CH2CH3
- M
- R3
- R4
- R5A
- R5B
- CH2
- H
- SCH3
- OH
- H
- CH2
- F
- SCH3
- OH
- H
- CH2
- H
- SCH3
- OCH3
- H
- CH2
- F
- SCH3
- OCH3
- H
- CH2
- H
- SCH3
- OCH2CH3
- H
- CH2
- F
- SCH3
- OCH2CH3
- H
- CH2
- OCH3
- SCH3
- OCH3
- H
- CH2
- OH
- SCH3
- OCH3
- H
- CH2
- Cl
- SCH3
- OCH3
- H
- CH2
- H
- SCH3
- CH3
- CH3
- CH2
- F
- SCH3
- CH3
- CH3
- CH2
- H
- SCH3
- CH3
- F
- CH2
- F
- SCH3
- CH3
- F
- CH2
- H
- N(CH3)2
- OCH3
- H
- CH2
- F
- N(CH3)2
- OCH3
- H
- CH2
- OCH3
- N(CH3)2
- OCH3
- H
- CH2
- OH
- N(CH3)2
- OCH3
- H
- CH2
- Cl
- N(CH3)2
- OCH3
- H
- CH2
- H
- SCH3
- OH
- H
- CH2
- F
- SCH3
- OH
- H
- CH2
- H
- SCH3
- OCH3
- H
- CH2
- F
- SCH3
- OCH3
- H
- CH2
- H
- SCH3
- OCH2CH3
- H
- CH2
- F
- SCH3
- OCH2CH3
- H
- CH2
- H
- SCH3
- CH3
- CH3
- CH2
- F
- SCH3
- CH3
- CH3
- CH2
- H
- SCH3
- CH3
- F
- CH2
- F
- SCH3
- CH3
- F
- CH2
- OCH3
- SCH3
- OCH3
- H
- CH2
- OH
- SCH3
- OCH3
- H
- CH2
- Cl
- SCH3
- OCH3
- H
- CH2
- H
- N(CH3)2
- OCH3
- H
- CH2
- F
- N(CH3)2
- OCH3
- H
- CH2
- OCH3
- N(CH3)2
- OCH3
- H
- CH2
- OH
- N(CH3)2
- OCH3
- H
- CH2
- Cl
- N(CH3)2
- OCH3
- H
- CH2
- H
- SCH3
- H
- H
- CH2
- F
- SCH3
- H
- H
- CH2
- OCH3
- SCH3
- H
- H
- CH2
- OH
- SCH3
- H
- H
- CH2
- Cl
- SCH3
- H
- H
- CH2
- H
- SCH3
- OH
- H
- CH2
- F
- SCH3
- OH
- H
- CH2
- OCH3
- SCH3
- OH
- H
- CH2
- OH
- SCH3
- OH
- H
- CH2
- Cl
- SCH3
- OH
- H
- CH2
- H
- N(CH3)2
- H
- H
- CH2
- F
- N(CH3)2
- H
- H
- CH2
- OCH3
- N(CH3)2
- H
- H
- CH2
- OH
- N(CH3)2
- H
- H
- CH2
- Cl
- N(CH3)2
- H
- H
- CH2
- H
- N(CH3)2
- OH
- H
- CH2
- F
- N(CH3)2
- OH
- H
- CH2
- OCH3
- N(CH3)2
- OH
- H
- CH2
- OH
- N(CH3)2
- OH
- H
- CH2
- Cl
- N(CH3)2
- OH
- H
- CH2
- H
- SCH3
- OCH3
- H
- CH2
- F
- SCH3
- OCH3
- H
- CH2
- OCH3
- SCH3
- OCH3
- H
- CH2
- OH
- SCH3
- OCH3
- H
- CH2
- Cl
- SCH3
- OCH3
- H
- CH2
- H
- N(CH3)2
- OCH3
- H
- CH2
- F
- N(CH3)2
- OCH3
- H
- CH2
- OCH3
- N(CH3)2
- OCH3
- H
- CH2
- OH
- N(CH3)2
- OCH3
- H
- CH2
- Cl
- N(CH3)2
- OCH3
- H
- CH2
- H
- SCH3
- OH
- H
- CH2
- F
- SCH3
- OH
- H
- CH2
- H
- SCH3
- OCH3
- H
- CH2
- F
- SCH3
- OCH3
- H
- CH2
- H
- SCH3
- OCH2CH3
- H
- CH2
- F
- SCH3
- OCH2CH3
- H
- CH2
- OCH3
- SCH3
- OCH3
- H
- CH2
- OH
- SCH3
- OCH3
- H
- CH2
- Cl
- SCH3
- OCH3
- H
- CH2
- H
- SCH3
- CH3
- CH3
- CH2
- F
- SCH3
- CH3
- CH3
- CH2
- H
- SCH3
- CH3
- F
- CH2
- F
- SCH3
- CH3
- F
- CH2
- H
- N(CH3)2
- OCH3
- H
- CH2
- F
- N(CH3)2
- OCH3
- H
- CH2
- OCH3
- N(CH3)2
- OCH3
- H
- CH2
- OH
- N(CH3)2
- OCH3
- H
- CH2
- Cl
- N(CH3)2
- OCH3
- H
- CH2
- H
- SCH3
- H
- H
- CH2
- F
- SCH3
- H
- H
- CH2
- OCH3
- SCH3
- H
- H
- CH2
- OH
- SCH3
- H
- H
- CH2
- Cl
- SCH3
- H
- H
- CH2
- H
- SCH3
- OH
- H
- CH2
- F
- SCH3
- OH
- H
- CH2
- OCH3
- SCH3
- OH
- H
- CH2
- OH
- SCH3
- OH
- H
- CH2
- Cl
- SCH3
- OH
- H
- CH2
- H
- N(CH3)2
- H
- H
- CH2
- F
- N(CH3)2
- H
- H
- CH2
- OCH3
- N(CH3)2
- H
- H
- CH2
- OH
- N(CH3)2
- H
- H
- CH2
- Cl
- N(CH3)2
- H
- H
- CH2
- H
- N(CH3)2
- OH
- H
- CH2
- F
- N(CH3)2
- OH
- H
- CH2
- OCH3
- N(CH3)2
- OH
- H
- CH2
- OH
- N(CH3)2
- OH
- H
- CH2
- Cl
- N(CH3)2
- OH
- H
- CH2
- H
- SCH3
- OCH3
- H
- CH2
- F
- SCH3
- OCH3
- H
- CH2
- OCH3
- SCH3
- OCH3
- H
- CH2
- OH
- SCH3
- OCH3
- H
- CH2
- Cl
- SCH3
- OCH3
- H
- CH2
- H
- N(CH3)2
- OCH3
- H
- CH2
- F
- N(CH3)2
- OCH3
- H
- CH2
- OCH3
- N(CH3)2
- OCH3
- H
- CH2
- OH
- N(CH3)2
- OCH3
- H
- CH2
- Cl
- N(CH3)2
- OCH3
- H
- CH2
- H
- SCH3
- CH3
- CH3
- CH2
- F
- SCH3
- CH3
- CH3
- CH2
- H
- SCH3
- CH3
- F
- CH2
- F
- SCH3
- CH3
- F
- CH2
- H
- SCH3
- —CH2CH2—
- CH2
- F
- SCH3
- —CH2CH2—
- CH2
- OCH3
- SCH3
- —CH2CH2—
- CH2
- OH
- SCH3
- —CH2CH2—
- CH2
- Cl
- SCH3
- —CH2CH2—
- CH2
- H
- N(CH3)2
- —CH2CH2—
- CH2
- F
- N(CH3)2
- —CH2CH2—
- CH2
- OCH3
- N(CH3)2
- —CH2CH2—
- CH2
- OH
- N(CH3)2
- —CH2CH2—
- CH2
- Cl
- N(CH3)2
- —CH2CH2—
- CH2
- H
- SCH3
- —CH2CH2—
- CH2
- F
- SCH3
- —CH2CH2—
- CH2
- OCH3
- SCH3
- —CH2CH2—
- CH2
- OH
- SCH3
- —CH2CH2—
- CH2
- Cl
- SCH3
- —CH2CH2—
- CH2
- H
- N(CH3)2
- —CH2CH2—
- CH2
- F
- N(CH3)2
- —CH2CH2—
- CH2
- OCH3
- N(CH3)2
- —CH2CH2—
- CH2
- OH
- N(CH3)2
- —CH2CH2—
- CH2
- Cl
- N(CH3)2
- —CH2CH2—
- CH2
- H
- SCH3
- —CH2CH2—
- CH2
- F
- SCH3
- —CH2CH2—
- CH2
- OCH3
- SCH3
- —CH2CH2—
- CH2
- OH
- SCH3
- —CH2CH2—
- CH2
- Cl
- SCH3
- —CH2CH2—
- CH2
- H
- N(CH3)2
- —CH2CH2—
- CH2
- F
- N(CH3)2
- —CH2CH2—
- CH2
- OCH3
- N(CH3)2
- —CH2CH2—
- CH2
- OH
- N(CH3)2
- —CH2CH2—
- CH2
- Cl
- N(CH3)2
- —CH2CH2—
- CH2
- H
- SCH3
- —CH2CH2—
- CH2
- F
- SCH3
- —CH2CH2—
- CH2
- OCH3
- SCH3
- —CH2CH2—
- CH2
- OH
- SCH3
- —CH2CH2—
- CH2
- Cl
- SCH3
- —CH2CH2—
- CH2
- H
- N(CH3)2
- —CH2CH2—
- CH2
- F
- N(CH3)2
- —CH2CH2—
- CH2
- OCH3
- N(CH3)2
- —CH2CH2—
- CH2
- OH
- N(CH3)2
- —CH2CH2—
- CH2
- Cl
- N(CH3)2
- —CH2CH2—
- CH2
- H
- SCH3
- —CH2CH2—
- CH2
- F
- SCH3
- —CH2CH2—
- CH2
- OCH3
- SCH3
- —CH2CH2—
- CH2
- OH
- SCH3
- —CH2CH2—
- CH2
- Cl
- SCH3
- —CH2CH2—
- CH2
- H
- N(CH3)2
- —CH2CH2—
- CH2
- F
- N(CH3)2
- —CH2CH2—
- CH2
- OCH3
- N(CH3)2
- —CH2CH2—
- CH2
- OH
- N(CH3)2
- —CH2CH2—
- CH2
- Cl
- N(CH3)2
- —CH2CH2—
- NH
- H
- SCH3
- —CH2CH2—
- NH
- F
- SCH3
- —CH2CH2—
- NH
- OCH3
- SCH3
- —CH2CH2—
- NH
- OH
- SCH3
- —CH2CH2—
- NH
- Cl
- SCH3
- —CH2CH2—
- NH
- H
- SCH3
- OCH3
- H
- NH
- F
- SCH3
- OCH3
- H
- NH
- OCH3
- SCH3
- OCH3
- H
- NH
- OH
- SCH3
- OCH3
- H
- NH
- Cl
- SCH3
- OCH3
- H
- NH
- H
- N(CH3)2
- —CH2CH2—
- NH
- F
- N(CH3)2
- —CH2CH2—
- NH
- OCH3
- N(CH3)2
- —CH2CH2—
- NH
- OH
- N(CH3)2
- —CH2CH2—
- NH
- Cl
- N(CH3)2
- —CH2CH2—
- NH
- H
- N(CH3)2
- OCH3
- H
- NH
- F
- N(CH3)2
- OCH3
- H
- NH
- OCH3
- N(CH3)2
- OCH3
- H
- NH
- OH
- N(CH3)2
- OCH3
- H
- NH
- Cl
- N(CH3)2
- OCH3
- H
- NH
- H
- SCH3
- —CH2CH2—
- NH
- F
- SCH3
- —CH2CH2—
- NH
- OCH3
- SCH3
- —CH2CH2—
- NH
- OH
- SCH3
- —CH2CH2—
- NH
- Cl
- SCH3
- —CH2CH2—
- NH
- H
- SCH3
- OCH3
- H
- NH
- F
- SCH3
- OCH3
- H
- NH
- OCH3
- SCH3
- OCH3
- H
- NH
- OH
- SCH3
- OCH3
- H
- NH
- Cl
- SCH3
- OCH3
- H
- NH
- H
- N(CH3)2
- —CH2CH2—
- NH
- F
- N(CH3)2
- —CH2CH2—
- NH
- OCH3
- N(CH3)2
- —CH2CH2—
- NH
- OH
- N(CH3)2
- —CH2CH2—
- NH
- Cl
- N(CH3)2
- —CH2CH2—
- NH
- H
- N(CH3)2
- OCH3
- H
- NH
- F
- N(CH3)2
- OCH3
- H
- NH
- OCH3
- N(CH3)2
- OCH3
- H
- NH
- OH
- N(CH3)2
- OCH3
- H
- NH
- Cl
- N(CH3)2
- OCH3
- H
- NH
- H
- SCH3
- H
- H
- NH
- F
- SCH3
- H
- H
- NH
- OCH3
- SCH3
- H
- H
- NH
- OH
- SCH3
- H
- H
- NH
- Cl
- SCH3
- H
- H
- NH
- H
- SCH3
- OH
- H
- NH
- F
- SCH3
- OH
- H
- NH
- OCH3
- SCH3
- OH
- H
- NH
- OH
- SCH3
- OH
- H
- NH
- Cl
- SCH3
- OH
- H
- NH
- H
- N(CH3)2
- H
- H
- NH
- F
- N(CH3)2
- H
- H
- NH
- OCH3
- N(CH3)2
- H
- H
- NH
- OH
- N(CH3)2
- H
- H
- NH
- Cl
- N(CH3)2
- H
- H
- NH
- H
- N(CH3)2
- OH
- H
- NH
- F
- N(CH3)2
- OH
- H
- NH
- OCH3
- N(CH3)2
- OH
- H
- NH
- OH
- N(CH3)2
- OH
- H
- NH
- Cl
- N(CH3)2
- OH
- H
- NH
- H
- SCH3
- OCH3
- H
- NH
- F
- SCH3
- OCH3
- H
- NH
- OCH3
- SCH3
- OCH3
- H
- NH
- OH
- SCH3
- OCH3
- H
- NH
- Cl
- SCH3
- OCH3
- H
- NH
- H
- SCH3
- H
- H
- NH
- F
- SCH3
- H
- H
- NH
- OCH3
- SCH3
- H
- H
- NH
- OH
- SCH3
- H
- H
- NH
- Cl
- SCH3
- H
- H
- NH
- H
- SCH3
- OH
- H
- NH
- F
- SCH3
- OH
- H
- NH
- OCH3
- SCH3
- OH
- H
- NH
- OH
- SCH3
- OH
- H
- NH
- Cl
- SCH3
- OH
- H
- NH
- H
- N(CH3)2
- H
- H
- NH
- F
- N(CH3)2
- H
- H
- NH
- OCH3
- N(CH3)2
- H
- H
- NH
- OH
- N(CH3)2
- H
- H
- NH
- Cl
- N(CH3)2
- H
- H
- NH
- H
- N(CH3)2
- OH
- H
- NH
- F
- N(CH3)2
- OH
- H
- NH
- OCH3
- N(CH3)2
- OH
- H
- NH
- OH
- N(CH3)2
- OH
- H
- NH
- Cl
- N(CH3)2
- OH
- H
- NH
- H
- SCH3
- OCH3
- H
- NH
- F
- SCH3
- OCH3
- H
- NH
- OCH3
- SCH3
- OCH3
- H
- NH
- OH
- SCH3
- OCH3
- H
- NH
- Cl
- SCH3
- OCH3
- H
- NH
- H
- SCH3
- OCH3
- H
- NH
- F
- SCH3
- OCH3
- H
- NH
- OCH3
- SCH3
- OCH3
- H
- NH
- OH
- SCH3
- OCH3
- H
- NH
- Cl
- SCH3
- OCH3
- H
- NH
- H
- SCH3
- —CH2CH2—
- NH
- F
- SCH3
- —CH2CH2—
- NH
- OCH3
- SCH3
- —CH2CH2—
- NH
- OH
- SCH3
- —CH2CH2—
- NH
- Cl
- SCH3
- —CH2CH2—
- NH
- H
- SCH3
- —CH2CH2—
- NH
- F
- SCH3
- —CH2CH2—
- NH
- OCH3
- SCH3
- —CH2CH2—
- NH
- OH
- SCH3
- —CH2CH2—
- NH
- Cl
- SCH3
- —CH2CH2—
- or a pharmaceutically acceptable salt thereof.
2,112 more elements
Dependencies are inferred from the claim text.