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US 11,377,422 B2Granted
Charged ion channel blockers and methods for use
AssigneeNocion Therapeutics, Inc.
InventorsBridget McCarthy Cole, James Lamond Ellis
Life of this patent
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Abstract
The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.
Claims13
A compound represented by Formula (I)
- wherein:
- Y−is a pharmaceutically acceptable anion;
- n is 2;
- RA and RB are alkyl and Rc is hydrogen;
- X1 is —NHC(O)—;
- each of RD and RE is independently selected from H, D, or alkyl;
- RH is selected from —CH2COOMe, benzyl, or unsubstituted alkyl;
- and
- R1B is phenyl.
6 more elements
Dependencies are inferred from the claim text.