Compounds and methods for treating influenza
AssigneeMacau University of Science and Technology
InventorsZhi-Hong Jiang, Nanshan Zhong, Zifeng Yang, Jingrong Wang, Qitong Feng, Xiaobo Zhou, Beixian Zhou
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Abstract
A compound including a structure of Formula (I) and a preparation method thereof, wherein R1 is —OH, —CH2OH, or —OCOCH3; R2, R3, and R4 are independently —H, —CH3 or —F, and at least one of R2, R3, and R4 is —F. A method for treating a subject suffering from a viral disease includes administering an effective amount of said compound or a solvate thereof to the subject.
Claims27
A compound comprising a structure of Formula (I)
- wherein R1 is —OH, —CH2OH, or —OCOCH3;
- R2, R3, and R4 are independently —H, —CH3 or —F, and at least one of R2 and R4 is —F.
A method of treating a subject suffering from a viral disease comprising administering an effective amount of a compound comprising a structure of Formula (I) or a solvate thereof to the subject,
- wherein R1 being —OH, —CH2OH, or —OCOCH3;
- R2, R3, and R4 being independently —H, —CH3 or —F, and at least one of R2 and R4 is —F.
A method of preparing a compound, comprising steps of:
- a) contacting a N-tert-butoxycarbonyl-protected amino acid (N-Boc-protected amino acid) of Formula (IV) with an amino alcohol of Formula (V), optionally in the presence of a coupling agent, under suitable condition to form a first intermediate of Formula (VI),
- wherein R2 and R4 are independently —H, —CH3 or —F,
- b) converting the first intermediate into an ester;
- c) removing a Boc group from the ester of the step b) to form a second intermediate;
- and
- d) contacting the second intermediate with a substituted or unsubstituted benzoyl chloride of Formula (VII) to form the compound
- wherein R3 is —H, —CH3 or —F.
Dependencies are inferred from the claim text.