Systems and methods for single isocenter radiotherapy of multiple targets
AssigneeDuke University
InventorsJustus Adamson, William Giles, Obed Laryea, Fang-Fang Yin
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Abstract
Systems and methods are provided for single isocenter radiotherapy of multiple targets. Conformal arc information may be used in a Conformal Arc Informed Volumetric Modulated Arc Therapy (CAVMAT) method that includes single isocenter radiotherapy of multiple targets where conformal multi-leaf collimator (MLC) trajectories may be used as the starting point for limited inverse optimization. Single isocenter radiotherapy of multiple targets may provide flexibility with less complex MLC trajectories, and fully block between targets with the MLC.
Claims18
A method for controlling a radiation therapy system, the method comprising:
- a) assigning radiotherapy targets into a target subgroup for an arc geometry;
- b) generating a conformal arc based on the arc geometry to maximize blocking between the radiotherapy targets of the target subgroup for radiotherapy;
- c) determining an initial radiotherapy dose based upon the conformal arc;
- d) generating weighted conformal arcs by determining field weights to deliver a radiotherapy dose with a conformity to the radiotherapy targets;
- e) performing an inverse optimization process on the weighted conformal arcs to adjust the radiotherapy dose and the conformity of the target subgroup;
- f) determining a final dose for the radiotherapy targets,
- wherein determining the field weights includes minimizing the dose difference to the radiotherapy targets as represented by:
- ΔD=|DRx−Σf(dtf×Wf)|
- where D represents dose to target t, dtf represents dose contribution to target t by field f, DRx represents prescription dose, and Wf represents weighting of field f.
A system for controlling a radiation therapy system, the system comprising:
- a computer system configured to:
- a) assign radiotherapy targets into a target subgroup for an arc geometry;
- b) generate a conformal arc based on the arc geometry to maximize blocking between the radiotherapy targets of the target subgroup for radiotherapy;
- c) determine an initial radiotherapy dose based upon the conformal arc;
- d) generate weighted conformal arcs by determining field weights to deliver a radiotherapy dose with a conformity to the radiotherapy targets;
- e) perform an inverse optimization process on the weighted conformal arcs to adjust the radiotherapy dose and the conformity of the target subgroup;
- f) determine a final dose for the radiotherapy targets, and
- wherein the computer system is further configured to determine the field weights by minimizing the dose difference represented by:
- ΔD=|DRx−Σf(dtf×Wf)|
- where D represents dose to target t, dtf represents dose contribution to target t by field f, DRx represents prescription dose, and Wf represents weighting of field f.
A computer readable medium, comprising:
- instructions stored on the computer readable medium for
- a) assigning a plurality of radiotherapy targets into a plurality of target subgroups for a plurality of arc geometries;
- b) generating conformal arcs based on the arc geometries to maximize blocking between the plurality of radiotherapy targets of the plurality of target subgroups for radiotherapy;
- c) determining initial radiotherapy doses based upon the conformal arcs;
- d) generating weighted conformal arcs by determining field weights to deliver a radiotherapy dose with a conformity to the plurality of radiotherapy targets;
- e) performing an inverse optimization process on the weighted conformal arcs to adjust the radiotherapy dose and the conformity of the plurality of target subgroups;
- f) determining a final dose for the plurality of radiotherapy targets, and
- wherein determining the field weights includes minimizing the dose difference to the radiotherapy targets as represented by:
- ΔD=|DRx−Σf(dtf×Wf)|
- where D represents dose to target t, dtf represents dose contribution to target t by field f, DRx represents prescription dose, and Wf represents weighting of field f.
Dependencies are inferred from the claim text.