Neurostimulation induced medicine devices and related methods of use

A system, comprising:

• an endotracheal device comprising:
• an elongate tubular member having a proximal end and a distal end;
• an inflatable cuff arranged between the proximal and distal ends of the elongate tubular member, wherein the inflatable cuff is configured to expand to contact a subject's tracheal wall;
• and
• an electrode array disposed in proximity to an exterior surface of the inflatable cuff, wherein the electrode array comprises a plurality of flexible electrodes, and wherein a set of the flexible electrodes anatomically align with a region of the subject's tracheal wall for selectively targeting vagus nerve activity;
• a stimulus generator operably coupled with the electrode array;
• and
• a controller operably coupled with the stimulus generator, the controller comprising a processor and memory operably coupled to the processor, the memory having computer-executable instructions stored thereon that, when executed by the processor, cause the controller to:
• sequentially negotiate the flexible electrodes of the electrode array to identify the set of the flexible electrodes by controlling the stimulus generator to deliver test signals to one or more of the flexible electrodes while monitoring the subject's physiological feedback signal;
• and
• control the stimulus generator to deliver a stimulus signal to the set of the flexible electrodes, wherein the stimulus signal is configured to modulate vagus nerve activity to achieve a therapeutic purpose.