Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device

An apparatus for delivering a therapeutic agent into a lumen of a gastrointestinal (GI) tract, the lumen having a lumen wall, the apparatus comprising:

• a tissue penetrating member formed from a therapeutically effective dose of at least one therapeutic agent;
• an actuator operably coupled to the tissue penetrating member;
• a swallowable capsule comprising a capsule wall that defines an interior, wherein the capsule wall encapsulates the tissue penetrating member to protect the therapeutically effective dose from degradation by digestive fluids within the GI tract while the swallowable capsule travels along at least a portion of the GI tract to a target treatment location of the GI tract;
• wherein the swallowable capsule is shaped to self-align with a wall of the GI tract at the target treatment location;
• and
• wherein the actuator comprises a first configuration and a second configuration, the tissue penetrating member being contained within the interior in the first configuration and expelled out of the interior in the second configuration so as to penetrate the lumen wall of the GI tract to deliver the therapeutic agent into the lumen wall at the target treatment location.