Extracellular matrix for treating pelvic floor disorders and skeletal muscle degeneration
AssigneeThe Regents of the University of California
InventorsKaren Christman, Marianna Alperin, Pamela Duran
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Abstract
Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases associated with muscular degeneration, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
Claims9
A method comprising administering by intramuscular injection in a subject with muscle degeneration an effective amount of a composition comprising decellularized extracellular matrix derived from skeletal muscle tissue, wherein the muscle degeneration in the subject is due to a condition selected from the group consisting of pelvic floor muscle (PFM) fibrosis, pelvic floor disorders (PFD), urinary incontinence (UI), fecal incontinence (FI), pelvic organ prolapse (POP), dysfunction of pelvic striated muscles, external urethral sphincteric (EUS) muscles, external anal sphincteric (EAS) muscles, rectal prolapse (RP), stress urinary incontinence (SUI), and mixed urinary incontinence (MUI).
Dependencies are inferred from the claim text.