Hydrogel composition and its uses
AssigneeSentigel AB
InventorsPeter Löwenhielm, Michael Malkoch, Oliver Andrén
Life of this patent
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Abstract
The present invention relates to an antibacterial co-polymer comprising a water soluble backbone polymer having in at least one end a dendritic or hyperbranched polymer of generation 1 to 6 wherein at least one functional group comprising a carboxylic amine has been covalently attached to the periphery of the dendritic or hyperbranched polymer. The present invention also relates to said anti-bacterial co-polymer when said co-polymer has been cross-linked with a cross-linking agent and to uses of the cross-linked co-polymer in a hydrogel for the treatment or prevention of bacterial infections, particularly in surgical site infections (SSIs).
Claims13
A method for the treatment of a bacterial infection, said method comprising administering to a subject in need thereof a pharmaceutically effective amount of a co-polymer selected from the group consisting of PEG10K-(G4-β-Alanin), PEG10K-(G5-β-Alanin), PEG10K-(G6-β-Alanin), PEG20K-(G4-β-Alanin), PEG20K-(G5-β-Alanin), PEG20K-(G6-β-Alanin), PEG2K-(G4-β-Alanin), PEG2K-(G5-β-Alanin), PEG2K-(G6-β-Alanin), PEG5K-(G4-β-Alanin), PEG5K-(G5-β-Alanin) and PEG5K-(G6-β-Alanin), a hyperbranched variant thereof, or any combination thereof.
A co-polymer comprising a water soluble backbone polymer having in at least one end a dendritic or hyperbranched polymer, wherein said dendritic or hyperbranched polymer is of generation 6 (G6) and wherein at least one functional group comprising a carboxylic amine is covalently attached to the periphery of the dendritic or hyperbranched polymer, wherein said co-polymer is selected from the group consisting of PEG20k-G6-(NH3+)128, PEG10k-G6-(NH3+)128, PEG5k-G6-(NH3+)128, and PEG2k-G6-(NH3+)128.
A kit of parts comprising:
- a) a dispenser comprising a co-polymer or a composition comprising a co-polymer, wherein said co-polymer is selected from the group consisting of PEG10K-(G4-β-Alanin), PEG10K-(G5-β-Alanin), PEG10K-(G6-β-Alanin), PEG20K-(G4-β-Alanin), PEG20K-(G5-β-Alanin), PEG20K-(G6-β-Alanin), PEG2K-(G4-β-Alanin), PEG2K-(G5-β-Alanin), PEG2K-(G6-β-Alanin), PEG5K-(G4-β-Alanin), PEG5K-(G5-β-Alanin) and PEG5K-(G6-β-Alanin), a hyperbranched variant thereof, or any combination thereof, and
- b) a dispenser comprising a cross-linking agent, said cross-linking agent comprising polyethylene glycol (PEG) having a molecular weight of 0.5 to 50 kDa.
A method for coating a surface of a human or animal body, or a surface of a medical implant, with a composition comprising a cross-linked co-polymer, said method comprising the steps of:
- a) mixing a solution comprising a co-polymer, wherein said co-polymer is selected from the group consisting of PEG10K-(G4-β-Alanin), PEG10K-(G5-β-Alanin), PEG10K-(G6-β-Alanin), PEG20K-(G4-β-Alanin), PEG20K-(G5-β-Alanin), PEG20K-(G6-β-Alanin), PEG2K-(G4-β-Alanin), PEG2K-(G5-β-Alanin), PEG2K-(G6-β-Alanin), PEG5K-(G4-β-Alanin), PEG5K-(G5-β-Alanin) and PEG5K-(G6-β-Alanin), a hyperbranched variant thereof, or any combination thereof, with a cross-linking agent, said cross-linking agent comprising polyethylene glycol (PEG) having a molecular weight of 0.5 to 50 kDa to yield a hydrogel comprising a cross-linked co-polymer, and thereafter;
- b) applying a coating of said hydrogel comprising said cross-linked co-polymer onto said surface, wherein said mixing is performed no more than about 10 minutes before the hydrogel is to be applied to said surface and wherein said coating has as a thickness of no less than 50 μm and up to about 400 μm.
Dependencies are inferred from the claim text.