Method of inducing an immune response using an expression construct and GLA
AssigneeAccess To Advanced Health Institute
InventorsSteven G. Reed, Darrick Carter
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Abstract
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.
Claims9
A method of eliciting or enhancing a desired antigen-specific immune response in a subject, the method comprising administering to the subject a composition comprising:
- (a) at least one recombinant expression construct which comprises a promoter operably linked to a nucleic acid sequence encoding at least one polypeptide antigen;
- and
- (b) a synthetic, substantially homogenous glucopyranosyl lipid adjuvant (GLA), wherein the GLA has the formula:
- where:
- R1, R3, R5 and R6 are C11 alkyl;
- and
- R2 and R4 are C13 alkyl.
Dependencies are inferred from the claim text.