Back to results
US 11,376,322 B2Granted
Compositions, methods and kits for eliciting an immune response
AssigneeDuke University
InventorsJohn H Sampson, Duane A Mitchell
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.
Claims34
A method of eliciting in a subject an immune response to a cancer cell that expresses a cytomegalovirus (CMV) antigen, the method comprising:
- selecting a subject in need of treatment related to the presence of the cancer cell;
- and
- administering to the subject a composition comprising a dendritic cell comprising a polynucleotide encoding a phosphoprotein unique long 83 (ppUL83;
- a/k/a pp65) or glycoprotein UL55 (gpUL55;
- a/k/a gB), or immunogenic fragments thereof wherein the composition, when administered to the subject, elicits an immune response to the cancer cell.
2 more elements
Dependencies are inferred from the claim text.