Method for removing anti-AAV antibodies from a blood-derived composition
AssigneesGenethon, Inserm (Institut National De La Sante Et De La Recherche Medicale), Sorbonne Universite, Association Institut De Myologie
InventorsBérangére Bertin, Carole Masurier, Otto-Wilhelm Merten, Federico Mingozzi
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Abstract
The present invention relates to a method for removing undesired anti-AAV antibodies from a blood-derived composition.
Claims17
A method for removing anti-adeno-associated virus (AAV) antibodies, from a blood-derived composition comprising contacting said blood-derived composition with at least one support onto which is grafted one or more affinity ligand(s) that bind to anti-AAV antibodies, wherein at least one affinity ligand is an empty AAV-8 particle.
A support onto which are grafted one or more affinity ligand that bind to one or more anti-AAV antibody, respectively, wherein at least one affinity ligand is an empty AAV-8 particle.
Dependencies are inferred from the claim text.