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US 11,376,320 B2Granted
Immunogenic and vaccine compositions against SARS-CoV-2
AssigneeIowa State University Research Foundation, Inc.
InventorMichael Wan Cho
Life of this patent
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Abstract
Disclosed herein are immunogenic and/or vaccine compositions and methods for treating or preventing Severe acute respiratory syndrome (SARS). The compositions and methods include an immunogenic portion of the receptor-binding domain (RBD) of the SARS-CoV-2-2 (COVID-19) spike protein. In at least particular cases, a mutated version of a portion of the RBD is utilized, such as a deglycosylated, or amino acid substituted mutant of the spike protein.
Claims14
An immunogenic composition comprising:
- a fragment of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, wherein the fragment is the receptor-binding domain (RBD) as set forth in SEQ ID NO:
- 45, and wherein the RBD is N-glycosylated;
- an adjuvant;
- and
- a carrier.
2 more elements
An immunogenic composition comprising:
- a polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:
- 3, wherein the polypeptide is N-glycosylated;
- an adjuvant;
- and
- a carrier.
2 more elements
Dependencies are inferred from the claim text.