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US 11,376,316 B2Granted
Breast cancer vaccines and methods of use thereof
AssigneeEtubics Corporation
InventorsJoseph P. Balint, Frank R. Jones, Richard B. Gayle
Life of this patent
Estimating the term…
Abstract
Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
Claims14
A composition comprising a replication defective adenovirus vector comprising:
- a deletion in an E2b region of the replication defective adenovirus vector;
- and
- a nucleic acid sequence encoding a tumor associated antigen, wherein the tumor associated antigen is a Her2/neu antigen.
A replication defective adenovirus comprising a genome deletion in an E2b region;
- and a nucleic acid coding sequence, wherein the improvement comprises:
- the nucleic acid coding sequence encodes a Her2/neu antigen, such that the adenovirus is capable of generating an immune response to Her2/neu antigen following administration of the adenovirus to an individual having preexisting immunity to adenovirus.
Dependencies are inferred from the claim text.