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US 11,376,312 B2Granted
Composition and method for treating nucleic acid-related eye disease
AssigneeThe Board of Trustees of the University of Illinois
InventorSandeep Jain
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Abstract
Provided herein is a composition and a method for treating nucleic acid-related eye disease.
Claims23
A topical composition for the treatment of a nucleic acid-related eye disease, wherein the composition is an isotonic composition and comprises a recombinant nuclease or a variant thereof and an ophthalmic excipient;
- wherein the ophthalmic excipient stabilizes the pH of the composition between 6.5 and 7.5 and maintains the isotonic environment of the composition;
- wherein the composition is hypo-osmolar or iso-osmolar as compared to the osmolarity of tear fluid from a subject without nucleic acid-related eye disease;
- and,
- wherein the composition does not contain an antibiotic.
1 more element
A method for the treatment of an ocular infection, comprising topically administering an effective amount of an isotonic composition
- to an ocular surface of an eye to remove nucleic acid from the ocular surface of the eye to treat the ocular infection;
- wherein the isotonic composition comprises a recombinant nuclease or a variant thereof and an ophthalmic excipient;
- wherein the ophthalmic excipient stabilizes the pH of the composition between 6.5 and 7.5 and maintains the isotonic environment of the composition;
- wherein the composition does not contain an antibiotic;
- and,
- wherein the recombinant nuclease is a DNase, an RNase, or a combination thereof.
3 more elements
Dependencies are inferred from the claim text.