Methods of treating microbial infection and inflammation
AssigneesColorado Seminary, Owner and Operator of University of Denver, The Regents of the University of Colorado, a body corporate
InventorsJohn Repine, Amani Alhalwani
Life of this patent
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Abstract
Methods of treating or preventing microbial infection in a subject in need of treatment by administering a therapeutically effective amount of ergothioneine, or functional analog, or prodrug, or salt thereof. Ergothioneine may be advantageously administered in conjunction with lactoferrin.
Claims12
A method for reducing, diminishing, or ameliorating irritation to, or inflammation of, an eye or to a skin region surrounding the eye, comprising administering to the eye or to the skin region surrounding the eye:
- a therapeutically effective amount of ergothioneine (ERGO), a precursor of ERGO, a salt thereof, or a biologically active analog or prodrug thereof, and
- a therapeutically effective amount of lactoferrin (LF), or a precursor of LF, a salt thereof, or a biologically active analog, or prodrug thereof,
- wherein the ERGO enhances an anti-microbial activity of the LF.
A method for reducing, diminishing, or ameliorating irritation to, or inflammation of, an eye or to a skin region surrounding the eye, comprising administering to the eye or to the skin region surrounding the eye:
- a therapeutically effective amount of ergothioneine (ERGO), a precursor of ERGO, a salt thereof, or a biologically active analog or prodrug thereof, and
- a therapeutically effective amount of lactoferrin (LF), or a precursor of LF, a salt thereof, or a biologically active analog, or prodrug thereof,
- wherein the LF has been exposed to a nitrating agent and the ERGO preserves the anti-microbial activity of the LF.
Dependencies are inferred from the claim text.