Pharmaceutical composition for preventing or treating dentin-dental pulp diseases or periodontal disease including CPNE4 protein
AssigneesHysensbio, Seoul National University R&Db Foundation
InventorsJoo Hwang Park, Ji Hyun Lee, Joo Cheol Park, Dong Seol Lee
Life of this patent
Estimating the term…
Abstract
Provided are compositions including a CPNE4 protein or a polynucleotide encoding thereof, a pharmaceutical composition, a quasi-drug composition, a dietary supplement, and a health functional food composition. A method for preventing or treating dentin-dental disease or periodontal disease and a method and a method for promoting regeneration of hard tissue including dentin, bone and cementum, and/or pulp tissue are disclosed.
Claims30
A method for preventing and/or treating dentin-dental pulp disease or periodontal diseases in a subject in need thereof, comprising administering an effective amount of a composition comprising a copine-4 (CPNE4) protein to the subject.
A method for regenerating a hard tissue in vitro comprising contacting the hard tissue with a copine-4 (CPNE4) protein,
- wherein the hard tissue is one or more selected from the group consisting of dentin, bone and cementum, and dental pulp tissue.
A method for promoting differentiation of non-dental mesenchymal stem cells into odontoblast, osteoblast, or cementoblast in vitro, comprising transplanting the non-dental mesenchymal stem cells with copine-4 (CPNE4) protein to the non-dental mesenchymal stem cell.
A method for preventing and/or treating dentin-dental pulp disease or periodontal diseases in a subject in need thereof, comprising administering an effective amount of a composition comprising a polynucleotide encoding copine-4 (CPNE4) protein to the subject.
A method for preventing and/or treating dentin-dental pulp disease or periodontal diseases in a subject in need thereof, comprising administering an effective amount of a composition comprising a vector comprising a polynucleotide encoding copine-4 (CPNE4) protein to the subject.
A method selected from the group consisting of:
- (a) method for regenerating a hard tissue in vitro comprising contacting the hard tissue with a polynucleotide encoding copine-4 (CPNE4) protein, wherein the hard tissue is one or more selected from the group consisting of dentin, bone and cementum, and dental pulp tissue;
- and
- (b) method for promoting differentiation of non-dental mesenchymal stem cells into odontoblast, osteoblast, or cementoblast in vitro comprising transplanting the non-dental mesenchymal stem cells with a polynucleotide encoding copine-4 (CPNE4) protein to the non-dental mesenchymal stem cell.
A method selected from the group consisting of:
- (a) method for regenerating a hard tissue in vitro comprising contacting the hard tissue with a vector comprising a polynucleotide encoding copine-4 (CPNE4) protein, wherein the hard tissue is one or more selected from the group consisting of dentin, bone and cementum, and dental pulp tissue;
- and
- (b) method for promoting differentiation of non-dental mesenchymal stem cells into odontoblast, osteoblast, or cementoblast in vitro comprising transplanting the non-dental mesenchymal stem cells with a vector comprising a polynucleotide encoding copine-4 (CPNE4) protein to the non-dental mesenchymal stem cell.
Dependencies are inferred from the claim text.