Peptides and uses therefor as antiviral agents
AssigneeViramatix Sdn Bhd
InventorMohamed Rajik Mohamed Ibrahim
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Abstract
Peptides with anti-viral properties are disclosed herein. The peptides include dextro (D) or a mixture of dextro/levo (L)-amino acids, possess anti-viral properties against multiple types of enveloped viruses and matrix protein layer viruses and are useful as pharmaceutical compositions for the treatment or prevention of enveloped virus and matrix protein layer virus infections.
Claims19
A method for treating an existing infection in a host animal, where the infection is caused at least in part by a virus containing a matrix protein layer or an enveloped virus, the method comprising administering a therapeutically effective amount of a peptide comprising the sequence twftfin or an analog or derivative of twftfin of the formula A1-A2-A3-A4-A5-A6-A7, where A1 is t or w, A2 is k or w, A3 is s or f, A4 is r or t, A5 is f, h, i, n, or w, A6 is i or d, and A7 is n or a, and where any one or any two of A1, A2, A3, A4, A5, A6, or A7 is optionally replaced with another D-amino acid or L-amino acid, where the peptide has a length of about 50 residues or less, or a pharmaceutical composition of any of the foregoing;
- where the virus is not an influenza virus or an orthomyxovirus.
Dependencies are inferred from the claim text.