Compositions and methods for treating nervous system injuries
AssigneeSanford Burnham Prebys Medical Discovery Institute
InventorsErkki Ruoslahti, Sazid Hussain, Aman Preet Singh Mann, Pablo Scodeller
Life of this patent
Estimating the term…
Abstract
Disclosed are methods and compositions for treating traumatic brain injury (TBI). A brain injury-specific 4-amino acid peptide (sequence CAQK), identified by in vivo phage display screening in mice with acute brain injury, shows selective binding to mouse and human brain injury lesions, and when systemically injected, specifically homes to sites of injury in penetrating and non-penetrating (controlled cortical impact) brain injury models. Significantly, the peptide alone produces therapeutic effect and so can be used in the absence of any other therapeutic compound.
Claims11
A method of treating a brain injury in a subject, the method comprising:
- administering to a subject having a brain injury a composition comprising an isolated peptide and a pharmaceutically acceptable carrier, wherein the peptide comprises the amino acid sequence CAQK (SEQ ID NO:4), wherein the composition does not comprise a cargo composition or cargo molecule,
- wherein the composition selectively homes to a site of the brain injury in the subject thereby treating the brain injury via the peptide at the site of the brain jury.
Dependencies are inferred from the claim text.