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US 11,376,290 B2Granted
Recombinant oncolytic virus, synthetic DNA sequence, and application thereof
AssigneeWuhan Boweid Biotechnology Co., Ltd.
InventorLigang Cai
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Abstract
A recombinant oncolytic virus, a synthetic DNA sequence and applications of the virus. The recombinant oncolytic virus includes a genome and an exogenous DNA sequence inserted in the genome. The exogenous DNA sequence adapts to express a basic peptide fragment, to increase the environmental pH in a host infected by the recombinant oncolytic virus. More than 60% of amino acids in the basic peptide fragment are basic amino acids. The recombinant oncolytic virus and the synthetic DNA sequence of the disclosure are used to prepare an anti-tumor drug.
Claims6
A recombinant oncolytic virus, comprising:
- an oncolytic virus genome and an exogenous DNA sequence inserted in the oncolytic virus genome, the exogenous DNA sequence being adapted to express a basic peptide fragment and to increase an environmental pH in a host infected by the recombinant oncolytic virus;
- wherein:
- the recombinant oncolytic virus is Coxsackie virus B3 strain, and
- the basic peptide fragment is Lys-Arg-Trp-His-Lys-Met-Arg-Lys-His (SEQ ID NO:
- 29).
2 more elements
Dependencies are inferred from the claim text.