Agent acting on transcellular ion transporter in intestinal tract, agent for activating chloride channel, agent for preventing or treating renal disease, or agent for promoting defecation

A composition comprising an effective amount of Bifidobacterium longum CLA8013 (Accession Number:

• NITE BP-02352), wherein said composition is a tablet, a pill, a chewable tablet, a troche, an emulsion, a syrup, an elixir, a soft drink, a lactic drink, fermented milk, yogurt, or a lactobacillus drink.

A method for activation of a transcellular ion transporter in the intestinal tract, the method comprising administering an agent comprising bacteria of the genus Bifidobacterium, or a treated product thereof to a subject in need, wherein the bacteria of the genus Bifidobacterium is Bifidobacterium longum CLA8013 (Accession Number:

• NITE BP-02352),
• wherein the treated product is selected from the group consisting of (i) a liquid mixture of the bacterial cells and solvent, (ii) a supernatant or centrifugation supernatant thereof, and (iii) a filtrate obtained by filtering the liquid mixture and the supernatant using a filter, and wherein the transcellular ion transporter is a chloride channel and wherein the method further comprises promoting defecation of the subject in need.