US 11,376,283 B2 · Stem cell material, compositions, and methods of use

Abstract

Aspects of the invention relate to a novel mesenchymal stem cell line (hb-MSC), a culture medium conditioned by the hb-MSC line, and various hb-MSC compositions. The hb-MSC compositions may include a plurality of hb-MSCs, the hb-MSC conditioned medium, or a combination thereof. The hb-MSC compositions may also include one or more of an antimicrobial agent, a film-forming agent, an appropriate carrier, as well as other additives as determined by the application. Also described are methods of use for the hb-MSC cells, the conditioned medium, and the compositions, including methods of treating or preventing bovine mastitis.

Claims24

Dependent claims

A cell-free composition comprising:

a mesenchymal stem cell conditioned medium, wherein the conditioned medium contains VEGF at a concentration of at least 760 pg/ml, TGF-β1 at a concentration of at least 67 pg/ml, TGF-β2 at a concentration of at least 170 pg/ml, and osteoprotegerin (OPG) at a concentration of less than 250 pg/ml.

Dependencies are inferred from the claim text.

Facts

Application

16/305,490Filed 31 May 2017

Priority

RU RU201612145831 May 2016

Published

US 2020/0360440 A119 Nov 2020

Granted

5 Jul 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 35/12
Medicinal preparations containing materials or reaction products thereof with undetermined constitution: materials from mammals; Compositions…
A61K 35/28
Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically…:…
A61K 9/0048
Galenical forms characterised by the site of application: eye, e.g. artificial tears
A61K 38/18
From animals; from humans: growth factors; Growth regulators

Stem cell material, compositions, and methods of use

Life of this patent

Stem cell material, compositions, and methods of use

Life of this patent

Abstract

Claims24