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US 11,376,270 B2Granted
Compositions containing decitabine, 5Azacytidine and tetrahydrouridine and uses thereof
AssigneeEpidestiny, Inc.
InventorsYogen Saunthararajah, Joseph Desimone, Henry Lau, Santhosh Vadivelu
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Abstract
Compositions comprising decitabine and tetrahydrouridine or 5-azacytidine and tetrahydrouridine for the treatment of cancer are disclosed. The compositions in the form of a pill is administered to a human subject sequentially or alternately guided by the measurement of predictive biomarkers.
Claims7
A composition for oral administration comprising:
- 5-azacytidine,
- tetrahydrouridine, and
- a pharmaceutically acceptable excipient, wherein the tetrahydrouridine and the 5-azacytidine are differentially located in the composition,
- wherein the composition comprises about 10 to about 100 mg/m2 of 5-azacytidine and about 400 to 500 mg/m2 of tetrahydrouridine, wherein the tetrahydrouridine and the 5-azacytidine are differentially located in the composition, wherein the composition is in the form of a pill or tablet or casule, and wherein the tetrahydrouridine is bio-available about 1 minute to about 180 minutes before the 5-azacytidine.
1 more element
A composition, for oral administration comprising:
- 5-azacytidine,
- tetrahydrouridine, and
- a pharmaceutically acceptable excipient, wherein the composition comprises about 10 to about 100 mg/m2 of 5-azacytidine and about 400 to 500 mg/m2 of tetrahydrouridine, wherein the tetrahydrouridine is bio-available about 1 minute to about 180 minutes before the 5-azacytidine, wherein the composition is in the form of a pill or tablet or capsule, and wherein the tetrahydrouridine is located on the surface and the 5-azacytidine is located inside the pill, tablet or capsule.
Dependencies are inferred from the claim text.