Organic compounds
AssigneeIntra-Cellular Therapies, Inc.
InventorsPeng Li, Wei Yao, Robert Davis, Sharon Mates, Kimberly Vanover, Gretchen Snyder
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Abstract
The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the μ-opioid receptor.
Claims19
A method for the treatment of a central nervous system disorder, comprising administering to a patient in need thereof a compound of a Formula I:
- wherein:
- X is —NH—;
- L is O;
- Z is —O— or —C(O)—;
- in free or salt form;
- optionally in an isolated or purified free or salt form;
- wherein the central nervous system disorder is (a) a pain disorder, and the patient also suffers from a gastrointestinal disorder and/or a pulmonary disorder, or (b) a pain disorder, wherein the pain disorder is traumatic pain and the patient also suffers from opioid use disorder.
Dependencies are inferred from the claim text.