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US 11,376,245 B2Granted
Dizocilpine derivatives as peripheral NMDA receptor antagonists
AssigneesInstitut National De La Sante Et De La Recherche Medicale (Inserm), Centre National de la Recherche Scientifique (CNRS), Universite Paris-Sud, Assistance Publique-HôPitaux De Paris (Aphp), Hopital Marie Lannelongue
InventorsSylvia Cohen-Kaminsky, Marc Humbert, Sebastien Dumas, Gilles Bru-Mercier, Samir Messaoudi, Jean-Daniel Brion, Mouad Alami, Gilles Galvani
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Abstract
The present invention relates to compounds of formula (I) for use as peripheral NMDA receptor antagonists.
Claims14
Compound of formula (I):
- wherein:
- R1 represents a cyclopropyl group;
- R2 represents a (C1-C10)alkyl group;
- n is 1;
- R3, R4, R5, R6, R7, R8, R9 and R10 represent a hydrogen atom;
- and X−is an anionic counterion selected from the group consisting of I−, Cl−, Br−and OH−.
3 more elements
Dependencies are inferred from the claim text.