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US 11,376,241 B2Granted
Aryl hydrocarbon receptor (AhR) modulator compounds
AssigneePhenex Pharmaceuticals AG
InventorsChristoph Steeneck, Ulrich Deuschle, Michael Albers, Thomas Hoffmann
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Abstract
The present invention relates to compounds which can act as aryl hydrocarbon receptor (AhR) modulators and, in particular, as AhR antagonists. The invention further relates to the use of the compounds for the treatment and/or prophylaxis of diseases and/or conditions through binding of said aryl hydrocarbon receptor by said compounds.
Claims14
A compound represented by Formula (I), an enantiomer, diastereomer, tautomer, or pharmaceutical acceptable salt thereof
- wherein
- A is
- wherein
- X is halogen, C1-6-alkyl, halo-C1-6-alkyl, or cyclopropyl,
- wherein the alkyl and cycloalkyl are unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of halogen, C1-3-alkyl, and halo-C1-3-alkyl;
- R5 is independently halogen or CN;
- and
- m is 0 to 4;
- B is
- R1, R2, R3 are each independently selected from hydrogen, halogen, C1-3-alkyl, halo-C1-3-alkyl, OH, O—C1-3-alkyl, and CN;
- and
- Rb is hydrogen or C1-6-alkyl.
9 more elements
A compound selected from the group consisting of
- tautomer, or pharmaceutical acceptable salt thereof.
Dependencies are inferred from the claim text.