Pharmaceutical combinations
AssigneeArray BioPharma Inc.
InventorsGiordano Caponigro, Zhu Alexander Cao
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Abstract
Provided herein are pharmaceutical combinations comprising (a) a B-Raf inhibitor, or a pharmaceutically acceptable salt thereof, (b) at least one mitogen activated protein kinase (MEK) inhibitor, or a pharmaceutically acceptable salt thereof, and (c) an epidermal growth factor receptor (EGFR) inhibitor or a pharmaceutically acceptable salt thereof; and optionally at least one pharmaceutically acceptable carrier; methods for preparing the pharmaceutical combinations, and the uses of the pharmaceutical combinations in the treatment of proliferative diseases, such as cancer.
Claims16
A method for increasing the overall survival, objective response rate, time to progression, progression-free survival, time-to-treatment failure, or Duration of Response (DOR) of a patient having a B-Raf mutant colorectal cancer, the method comprising administering to a patient in need thereof a combination therapy comprising therapeutically effective amounts, independently, of:
- (a) a BRAF inhibitor which is methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate (COMPOUND A) or a pharmaceutically acceptable salt thereof,
- (b) MEK inhibitor (COMPOUND B) which is 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid(2-hydroxyethoxy)-amide, or a pharmaceutically acceptable salt thereof, and
- (c) an anti-EGFR antibody (COMPOUND C) which is cetuximab.
Dependencies are inferred from the claim text.