Methods and compositions for the treatment of retinopathy and other ocular diseases
AssigneeLankenau Institute for Medical Research
InventorsAlexander J. Muller, Arturo Bravo-Nuevo, Arpita Mondal, Courtney Smith, Hollie E. Flick
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Abstract
Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.
Claims15
A method for treating an ocular disease characterized by abnormal vascularization, in a subject in need thereof, the method comprising reducing, inhibiting or ablating activity or expression of indoleamine 2,3 dioxygenase-1 (IDO-1) in an eye of the subject.
A method for treating diabetic retinopathy, in a subject in need thereof, the method comprising reducing, inhibiting or ablating activity or expression of indoleamine 2,3 dioxygenase-1 (IDO-1) in an eye of the subject.
Dependencies are inferred from the claim text.