Polymer particles for neutrophil injury
AssigneeThe Regents of the University of Michigan
InventorsOmolola Eniola-Adefeso, William Kelley, Theodore Standiford
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Abstract
Provided herein are methods of treatment, compositions, systems and kits using polymer particles as restraints of neutrophil function. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which neutrophils may be implicated. In some embodiments, polymer particles are useful for diagnosing neutrophil related diseases or conditions.
Claims12
A method of treating or ameliorating a neutrophil-mediated condition in a patient wherein said neutrophil-mediated condition is acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS), comprising administering to said patient a therapeutically effective amount of a salicylate polyanhydride ester that hydrolyzes to salicylic acid (Poly-A) particle wherein said Poly-A particle is a vascular-targeted Poly-A particle (VTP) wherein a surface of said VTP is bound with an antibody or ligand that targets one or more proteins expressed on a vascular wall and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.