Hydrocortisone acetate suppository formulation for treatment of disease
AssigneeCristcot LLC
InventorsJennifer J. Davagian, Raj Devarajan
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Abstract
The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
Claims24
A drug delivery element comprising:
- a component having a first shape external from a rectum and configured to form a second shape internal to the rectum, the second shape having a configuration to expose a drug to tissues of the rectum, the drug delivery element being sized and shaped to be placed entirely within the rectum, wherein the drug is a formulation comprising hydrocortisone acetate and colloidal silicone dioxide.
A drug delivery element comprising:
- a component having a first shape external from a rectum and configured to form a second shape internal to the rectum, the second shape having a configuration to expose a drug to tissues of the rectum, the component including a ring, wherein the ring is folded into a loop within a loop when the component has the first shape.
A drug delivery element comprising:
- a component having a first shape external from a rectum and configured to form a second shape internal to the rectum, the second shape having a configuration to expose a drug to tissues of the rectum, the component including a central portion and plural arms extending from the central portion, wherein the central portion and arms are arranged to allow gas flow through the central portion.
A drug delivery element comprising:
- a component having a first shape external from a rectum and configured to form a second shape internal to the rectum, the second shape having a configuration to expose a drug to tissues of the rectum, the component including a central portion and plural arms extending from the central portion, wherein the arms are in the shape of petals.
A drug delivery element comprising:
- a component having a first shape external from a rectum and configured to form a second shape internal to the rectum, the second shape having a configuration to expose a drug to tissues of the rectum, the component including one or more filaments configured to expose the drug to the tissue.
A drug delivery element comprising:
- a corrugated component having a first shape external from a rectum and configured to form a second shape internal to the rectum, the second shape having a configuration to expose a drug to tissues of the rectum, the drug delivery element being sized and shaped to be placed entirely within the rectum.
A drug delivery element comprising:
- a component having a first shape external from a rectum and configured to form a second shape internal to the rectum, the second shape having a configuration to expose a drug to tissues of the rectum, the component including one or more raised bumps on a side of the component, the drug delivery element being sized and shaped to be placed entirely within the rectum.
A drug delivery element in combination with an insertion device, comprising:
- a component having a first shape external from a rectum and configured to form a second shape internal to the rectum, the second shape having a configuration to expose a drug to tissues of the rectum, the drug delivery element being sized and shaped to be placed entirely within the rectum;
- and
- the insertion device comprising a barrel to hold the component when in the first shape, and a plunger to release the component from the barrel to administer the component into the rectum.
Dependencies are inferred from the claim text.