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US 11,376,216 B2Granted
Periodontal disease therapy
AssigneeNew York University
InventorsXin Li, Deepak Saxena
Life of this patent
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Abstract
Disclosed are formulations for oral films and other compositions containing therapeutic agents. The therapeutic agents interfere with succinate/succinate receptor signaling. The films and compositions of the present disclosure can be used to treat periodontal disease.
Claims16
An oral thin film having a thickness of from 0.05 mm to 0.4 mm comprising an inhibitor of the succinate/succinate receptor 1 signaling pathway in the oral cavity, and a polymer, wherein the inhibitor of succinate/succinate receptor has the following structure or a succinate salt thereof:
- where R is selected from the group consisting of a hydrogen atom, an alkyl group, COOR′ group, and
- where R′ is an alkyl group and R″ is selected from the group consisting of a hydrogen atom, an alkyl group, and
Dependencies are inferred from the claim text.