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US 11,376,214 B2Granted
Compositions and methods for treatment of ocular diseases
AssigneeKiora Pharmaceuticals, Inc.
InventorsBrenda K. Mann, Hee-Kyoung Lee
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to compositions and methods for treating ocular diseases with antibiotics. In particular, the disclosure relates to non-blurring, antibiotic-containing hydrogel compositions that have an extended contact time on the eye and do not interfere with wound healing.
Claims27
An ocular composition, comprising:
- a shear-thinning hydrogel comprising a thiolated hyaluronic acid (HA), wherein the thiolated HA is at a concentration of about 3 to about 8 mg/ml and is covalently crosslinked, and a thiol modification of the thiolated HA is between about 0.05 to about 0.15 μmol thiol/mg;
- and
- an antibiotic at a concentration of about 1 to about 10 mg/ml,
- wherein the ocular composition is in the form of an eyedrop.
1 more element
An ocular composition, comprising:
- a shear-thinning hydrogel comprising thiolated hyaluronic acid (HA), wherein the thiolated HA is at a concentration of about 3 to about 8 mg/ml and is disulfide crosslinked, and a thiol modification of the thiolated HA is between about 0.05 to about 0.15 μmol thiol/mg;
- and
- an antibiotic at a concentration of about 1 to about 10 mg/ml,
- wherein upon application, the shear-thinning hydrogel resides on an eye of a patient for between about 30 minutes and about 2 hours, and
- wherein the ocular composition is in the form of an eyedrop.
2 more elements
Dependencies are inferred from the claim text.