Topical pharmaceutical formulation
AssigneeFutura Medical Developments Limited
InventorsAdrian Davis, Marc Barry Brown
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Abstract
There is described a topical composition for application of an NSAID comprising ibuprofen, the composition comprising a solution or suspension of the NSAID as active ingredient in a residual carrier system comprising a polyhydric alcohol, a glycol ether, an ester of a higher fatty acid and optionally water, the ingredients of the residual carrier system having the following concentrations in percentages by weight: polyhydric alcohol 50-90 glycol ether 7.5-40 ester 0.5-5 water optional in which either the composition or the residual phase is in a single phase under ambient conditions and the maximum water concentration is that above which the composition or the residual phase exhibits signs of inhomogeneity.
Claims19
A topical composition for application of an NSAID comprising ibuprofen, the composition comprising a solution or suspension of the NSAID as active ingredient in a residual carrier system comprising a polyhydric alcohol, a glycol ether, an alkyl ester of a C10 to C20 fatty acid and optionally water, the ingredients of the residual carrier system having the following concentrations in percentages by weight:
- polyhydric alcohol 50-90
- glycol ether 7.5-40
- alkyl ester of a C10 to C20 fatty acid 0.5-5
- water 0-20
- in which either the composition or a residual phase formed by the residual carrier system is in a single phase under ambient conditions, wherein the NSAID is supersaturated in the residual phase, and
- wherein the composition includes a volatile neutralizing agent and has a pH of 6 to 8 before application to the skin.
Dependencies are inferred from the claim text.