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US 11,375,929 B2Granted
Method and device for detection of bioavailable drug concentration in a fluid sample
AssigneesUniversity of Tennessee Research Foundation, The University of Memphis Research Foundation
InventorsEdward Chaum, Erno Lindner
Life of this patent
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Abstract
The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.
Claims20
An electrochemical voltammetric sensor device comprising,
- a body comprising a first lumen;
- a securing body comprising a second lumen;
- a flexible circuit comprising a connection end and a sensor end, wherein the flexible circuit comprises a flexible strip of material;
- wherein the flexible strip of material comprises a first layer and a second layer, wherein the first layer and the second layer comprise polyamide;
- the connection end comprising a plurality of vias;
- the sensor end comprising an electrochemical sensor, wherein the electrochemical sensor comprises a first array of electrodes, wherein the first array of electrodes are electrically connected to the vias using conductive traces, wherein the first array of electrodes comprises a water-immiscible coating that surrounds the first array of electrodes, wherein the coating partitions a hydrophobic drug from a fluid sample;
- wherein the body resides within the second lumen of the securing body, wherein an upper surface of the flexible circuit is adjacent and conforms to an interior circumferential curvature of the second lumen,
- wherein a lower surface of the flexible circuit is adjacent and conforms to an exterior circumferential curvature of the body;
- the securing body comprising a first opening positioned above the first array of electrodes,
- wherein the first opening exposes the first array of electrodes to the fluid sample.
7 more elements
An electrochemical voltammetric sensor device comprising, a body comprising a first lumen;
- a securing body comprising a second lumen;
- a flexible circuit comprising a connection end and a sensor end;
- the connection end comprising a plurality of vias;
- wherein pins of a mating connector pass through corresponding vias of the connection end, wherein the pins and the connection end are joined by soldering the pins to the corresponding vias;
- the sensor end comprising an electrochemical sensor, wherein the electrochemical sensor comprises a first array of electrodes, wherein the first array of electrodes are electrically connected to the vias using conductive traces, wherein the first array of electrodes comprises a water-immiscible coating that surrounds the first array of electrodes, wherein the coating partitions a hydrophobic drug from a fluid sample;
- wherein the body resides within the second lumen of the securing body, wherein an upper surface of the flexible circuit is adjacent and conforms to an interior circumferential curvature of the second lumen;
- wherein a lower surface of the flexible circuit is adjacent and conforms to an exterior circumferential curvature of the body;
- and
- wherein the securing body comprises a first opening positioned above the first array of electrodes, wherein the first opening exposes the first array of electrodes to the fluid sample.
6 more elements
Dependencies are inferred from the claim text.