Oxygen reduction disposable kits, devices and methods of use thereof

An oxygen depletion device 10 for depleting oxygen from blood comprising:

• an outer receptacle 101 substantially impermeable to oxygen;
• an inner collapsible blood container 102 comprising one or more chambers comprising polyvinyl chloride (PVC) or polyolefin;
• a spacer 110 situated between said outer receptacle 101 and said inner collapsible blood container 102;
• and an oxygen sorbent 103 situated between said outer receptacle 101 and said inner collapsible blood container 102,
• wherein said spacer 110 is a mesh comprising at least one interstice 111 and maintains a headspace defined by said outer receptacle 101 and said inner collapsible blood container 102, wherein said at least one interstice 111 comprises between 50% to 80% of the total area of said mesh material of said spacer 110, and wherein said headspace ensures efficient diffusion of oxygen from a surface of said inner collapsible blood container 102 to said oxygen sorbent 103.