Liquid pumping cassettes and associated pressure distribution manifold and related methods

A fluid handling cassette comprising a mid-plate positioned between a first plate and a second plate, said plates having a length, a width and a plate thickness, a first side of the mid-plate opposing the first plate and a second side of the mid-pate opposing the second plate;

• the first plate spaced apart from the mid-plate defining a width of a first inter-plate space, and the second plate spaced apart from the mid-plate defining a width of a second inter-plate space;
• an edge of the cassette having a cassette thickness defined by the thickness of each plate plus the width of the first and second inter-plate spaces, and a face of the cassette being defined by the length and width of the first or second plate;
• the mid-plate comprising a valve station defined by a valve diaphragm and the first side of the mid-plate, said valve diaphragm seated against the first side of the midplate and having an excursion range defined by the width of the first inter-plate space;
• and
• a valve actuation channel running parallel to the face of the cassette in the first inter-plate space connecting a valve actuation chamber bounded by the first plate and the valve diaphragm with a cassette valve actuation port located within the first inter-plate space at a first edge of the cassette.

A fluid handling cassette comprising a mid-plate positioned between a first plate and a second plate, said plates having a length, a width and a plate thickness, a first side of the mid-plate opposing the first plate and a second side of the mid-pate opposing the second plate;

• the first plate spaced apart from the mid-plate defining a width of a first inter-plate space, and the second plate spaced apart from the mid-plate defining a width of a second inter-plate space;
• an edge of the cassette having a cassette thickness defined by the thickness of each plate plus the width of the first and second inter-plate spaces, and a face of the cassette being defined by the length and width of the first or second plate;
• the mid-plate comprising a pump station defined by a pump diaphragm and the first side of the mid-plate, said pump diaphragm seated against the first side of the mid-plate and having an excursion ranged defined by the width of the first inter-plate space;
• the mid-plate also comprising first and second valve stations, each defined by a valve diaphragm and the first side of the mid-plate, said valve diaphragm seated against the first side of the midplate and having an excursion range defined by the width of the first inter-plate space;
• and
• a pump actuation channel for the pump station, and a valve actuation channel for each of the first and second valve stations;
• said pump actuation channel running parallel to the face of the cassette in the first inter-plate space connecting a pump actuation chamber bounded by the first plate and the pump diaphragm with a cassette pump actuation port located within the first inter-plate space at a first edge of the cassette;
• and
• each said valve actuation channel running parallel to the face of the cassette in the first inter-plate space connecting a valve actuation chamber bounded by the first plate and the valve diaphragm with a cassette valve actuation port located within the first inter-plate space at the first edge of the cassette.

A fluid handling cassette comprising a mid-plate positioned between a first plate and a second plate, said plates having a length, a width and a plate thickness, a first side of the mid-plate opposing the first plate and a second side of the mid-pate opposing the second plate;

• the first plate spaced apart from the mid-plate defining a width of a first inter-plate space, and the second plate spaced apart from the mid-plate defining a width of a second inter-plate space;
• an edge of the cassette having a cassette thickness defined by the thickness of each plate plus the width of the first and second inter-plate spaces, and a face of the cassette being defined by the length and width of the first or second plate;
• the mid-plate comprising first and second valve stations, the first valve station defined by a first valve diaphragm and the first side of the mid-plate, and the second valve station defined by a second valve diaphragm and the second side of the mid-plate, said first valve diaphragm seated against the first side of the midplate and having an excursion range defined by the width of the first inter-plate space, and said second valve diaphragm seated against the second side of the mid-plate and having an excursion range defined by the width of the second inter-plate space;
• and
• a first valve actuation channel for the first valve station and running parallel to the face of the cassette in the first inter-plate space, and a second valve actuation channel for the second valve station and running parallel to the face of the cassette in the second inter-plate space;
• said first valve actuation channel connecting a first valve actuation chamber bounded by the first plate and the first valve diaphragm with a first cassette valve actuation port located within the first inter-plate space at a first edge of the cassette;
• and
• said second valve actuation channel connecting a second valve actuation chamber bounded by the second plate and the second valve diaphragm with a second cassette valve actuation port located within the second inter-plate space at the first edge of the cassette.

A fluid handling cassette comprising a mid-plate positioned between a first plate and a second plate, said plates having a length, a width and a plate thickness, a first side of the mid-plate opposing the first plate and a second side of the mid-pate opposing the second plate;

• the first plate spaced apart from the mid-plate defining a width of a first inter-plate space, and the second plate spaced apart from the mid-plate defining a width of a second inter-plate space;
• an edge of the cassette having a cassette thickness defined by the thickness of each plate plus the width of the first and second inter-plate spaces, and a face of the cassette being defined by the length and width of the first or second plate;
• the mid-plate comprising first and second pump stations, the first pump station defined by a first pump diaphragm and the first side of the mid-plate, and the second pump station defined by a second pump diaphragm and the second side of the mid-plate, said first pump diaphragm seated against the first side of the midplate and having an excursion range defined by the width of the first inter-plate space, and said second pump diaphragm seated against the second side of the mid-plate and having an excursion range defined by the width of the second inter-plate space;
• and
• a first pump actuation channel for the first pump station and running parallel to the face of the cassette in the first inter-plate space, and a second pump actuation channel for the second pump station and running parallel to the face of the cassette in the second inter-plate space;
• said first pump actuation channel connecting a first pump actuation chamber bounded by the first plate and the first pump diaphragm with a first cassette pump actuation port located within the first inter-plate space at a first edge of the cassette;
• and
• said second pump actuation channel connecting a second pump actuation chamber bounded by the second plate and the second pump diaphragm with a second cassette pump actuation port located within the second inter-plate space at the first edge of the cassette.