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US 11,371,066 B2Granted
Generation of acyl alcohols
AssigneeModular Genetics, Inc.
InventorKevin A. Jarrell
Life of this patent
Estimating the term…
Abstract
Methods, compositions, and cells for generating acyl alcohols. Compositions comprising acyl alcohols. Methods of cleaving acyl amino acids and/or acyl alcohols to generate free fatty acids, free amino acids, and/or free alcohols.
Claims18
A composition comprising an acyl amino alcohol and an intact engineered microbial cell or one or more components thereof,
- wherein the engineered intact microbial cell or one or more components thereof comprises one or more polypeptides, which collectively comprises:
- a fatty acid linkage domain comprising a condensation domain of a SrfA subunit of Bacillus subtilis's surfactin synthetase,
- a single peptide synthetase domain comprising an adenylation domain of a glycine module of Bacillus brevis's gramicidin peptide synthetase, and
- one or more reductase polypeptides comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:
- 1, and
- wherein the one or more reductase polypeptides are collectively capable of reducing an acyl amino acid to an acyl amino alcohol.
3 more elements
Dependencies are inferred from the claim text.